PMX 53 acetate(219639-75-5 free base) ( —— )

产品货号. M37923 CAS No. 852629-88-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

PMX 53 acetate(219639-75-5 free base)
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2).
产品描述

PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2).
体外实验

——
体内实验

——
同义词

——
通路

Immunology/Inflammation
靶点

Complement System
受体

Complement System
研究领域

——
适应症

——

CAS Number

852629-88-0
分子量

956.16
分子式

C49H69N11O9
纯度

>98% (HPLC)
溶解度

——
SMILES

N=C(N)NCCC[C@@H]1NC([C@H](CC2=CNC3=C2C=CC=C3)NC([C@@H](CC4CCCCC4)NC([C@H]5N(C([C@H](CCCNC1=O)NC([C@H](CC6=CC=CC=C6)NC(C)=O)=O)=O)CCC5)=O)=O)=O.CC(O)=O
化学全称

——

计算器

产品手册

关联产品

Lipoteichoic acid

Lipoteichoic acid 是 Staphylococcus aureus 细胞壁的成分，通过诱导 C3 和抑制 CD55 来激活补体系统。
(Z)-Leukadherin-1

(Z)-Leukadherin-1 是 CD11b 的变构激动剂。
Factor D inhibitor 6

Factor D抑制剂6是一种有效的、选择性的、口服生物可利用的D因子抑制剂，IC50为30 nM。